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Risk Factors for Severe Coronary Artery Disease - A Case-Control Study of Patients Who Have Undergone Coronary Artery Bypass Grafting

Accession number;06A0174936

Title;Risk Factors for Severe Coronary Artery Disease - A Case-Control Study of Patients Who Have Undergone Coronary Artery Bypass Grafting

Author; KOSUGE KEIICHIRO (Diabetes Center, Niigata-kobari Hospital, Niigata, Jpn) KOSUGE KEIICHIRO (Div. Of Endocrinology And Metabolism, Dep. Of Homeostatic Regulation And Developments, Niigata Univ. Graduate School ...) SASAKI HIDEO (Diabetes Center, Niigata-kobari Hospital, Niigata, Jpn) IKARASHI TOMOO (Diabetes Center, Niigata-kobari Hospital, Niigata, Jpn) IKARASHI TOMOO (Div. Of Endocrinology And Metabolism, Dep. Of Homeostatic Regulation And Developments, Niigata Univ. Graduate School ...) TOYABE SHINICHI (Dep. Of Medical Informatics, Niigata Univ. Medial And Dental Hospital, Niigata, Jpn) AKAZAWA KOHEI (Dep. Of Medical Informatics, Niigata Univ. Medial And Dental Hospital, Niigata, Jpn) KOBAYASHI CHIAKI (Div. Of Endocrinology And Metabolism, Dep. Of Homeostatic Regulation And Developments, Niigata Univ. Graduate School ...) ABE ERI (Div. Of Endocrinology And Metabolism, Dep. Of Homeostatic Regulation And Developments, Niigata Univ. Graduate School ...) SUZUKI AKIKO (Div. Of Endocrinology And Metabolism, Dep. Of Homeostatic Regulation And Developments, Niigata Univ. Graduate School ...) SAITO HIROFUMI (Div. Of Cardiovascular Surgery, Niigata-kobari Hospital, Niigata, Jpn) EGUCHI SHOJI (Div. Of Cardiovascular Surgery, Niigata-kobari Hospital, Niigata, Jpn) OTSUKA HIDEAKI (Div. Of Cardiovascular Medicine, Niigata-kobari Hospital, Niigata, Jpn) AIZAWA YOSHIFUSA (Div. Of Endocrinology And Metabolism, Dep. Of Homeostatic Regulation And Developments, Niigata Univ. Graduate School ...)

Journal Title;J Atheroscler Thromb

Journal Code:L2187A

ISSN:1340-3478

VOL.13;NO.1;PAGE.62-67 (J-STAGE)(2006)

Figure&Table&Reference;TBL.5, REF.22

Pub. Country;Japan

Language;English

Abstract;To investigate risk factors for coronary artery disease (CAD), we analyzed the clinical parameters of patients with a coronary artery bypass graft (CABG) in a case-control study. Eighty-eight patients (75 males and 13 females) who underwent CABG surgery between 2001 and 2002 were compared with age- and sex-matched healthy controls randomly chosen from the registry of Kobari Health Care Center. Wilcoxon's signed rank test and McNemar's test were used for pairwise comparisons. Multivariate logistic regression analysis was used to identify significant risk factors for CABG. Significant differences between the patients and controls were observed in HDL-C (p < 0.001), HbA1c (p < 0.001), Brinkman Index (BI; p < 0.001), body mass index (BMI; p = 0.002), and systolic blood pressure (SBP; p = 0.013). Subjects with an abnormal BMI, HbA1c, or HDL-C or high BI value made up a significantly higher proportion of the patients who underwent CABG, compared to their age- and sex-matched controls. Multivariate logistic regression analysis identified high levels of HbA1c, low levels of HDL-C, and high scores on the BI as significant risk factors for needing a CABG. These results demonstrate that, despite the modification of laboratory determinations by antecedent treatment, HDL-C, HbA1c, BI, BMI, and SBP are significant indicators of risk for CAD. (Author abst.)

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