Long-term Effect of Nifedipine CR Tablet in Patients with Poor Blood Pressure Control-Comparison with Amlodipine-
|
Accession number;06A0251100
|
| Title;Long-term Effect of Nifedipine CR Tablet in Patients with Poor Blood Pressure Control-Comparison with Amlodipine- |
| Author;
MATSUNAGA AKIRA
(Fukuokadai I Junkankika)
ARISHIMA HIROAKI
(Fukuokadai I Junkankika)
NIIMURA HIDEYA
(Fukuokadai I Junkankika)
SAKU KEIJIRO
(Fukuokadai I Junkankika)
|
Journal Title;Ther Res
|
Journal Code:Y0681A
|
ISSN:0289-8020
|
|
VOL.27;NO.3;PAGE.489-495(2006)
|
| Figure&Table&Reference;FIG.4, TBL.2, REF.11 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Nifedipine CR tablets (nifedipine) were administered in place of a hypotensive drug, amlodipine, to examine its efficacy and safety in patients for whom amlodipine therapy failed to achieve the goal specified in the guidelines for the management of hypertension (JSH2004). Patients and methods: Amlodipine was switched to nifedipine in patients whose blood pressure was poorly controlled in spite of hypotensive therapies based on amlodipine given for at least three months on an outpatient basis. The patients were then followed for one year. Nifedipine was started at 20 mg/day for patients previously treated with 5 mg/day of amlodipine. For patients treated with 10 mg/day of amlodipine, it was started at 20 mg/day and, if the physician considered it inadequate, increased up to 40 mg/ day. Results and discussion: Of 30 patients who started nifedipine in place of amlodipine, three patients discontinued nifedipine: two due to lower limb itching and headache, one patient discontinued it six months later for receiving the treatment of another disease. The mean systolic/diastolic blood pressure values in 28 evaluable patients (mean age: 65.1 .+-. 11.6 years) were significantly reduced from 159.1 .+-. 14.4/92.2 .+-. 7.6 mmHg at the switch to 140.1 .+-. 10.8/85.5 .+-. 7.6 mmHg at 12 months (p < 0.01). The significantly higher hypotensive effect of nifedipine was also confirmed in 14 patients who replaced 5 mg/day of amlodipine with 20 mg/day of nifedipine. No significant change was observed for pulse rate throughout the follow-up period. Thus, nifedipine provided obvious hypotensive effect without increasing pulse rate. The percentage of patients who achieved the target blood pressure as recommended by JSH2004 was increased from 0% during the amlodipine therapy to 45.0% during the nifedipine therapy. However, it is considered necessary to further increase the percentage. (author abst.) |
|
|
|
Related Articles;
|
|
