Effect of Cilnidipine on the Urinary Albumin Excretion and Urinary Fibronectin Levels in Hypertensive Type 2 Diabetes Patients with Early Nephropathy
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Accession number;06A0251101
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| Title;Effect of Cilnidipine on the Urinary Albumin Excretion and Urinary Fibronectin Levels in Hypertensive Type 2 Diabetes Patients with Early Nephropathy |
| Author;
TADA HISAYA
(Tadennaikaiin(matsumotoshi))
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Journal Title;Ther Res
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Journal Code:Y0681A
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ISSN:0289-8020
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VOL.27;NO.3;PAGE.497-502(2006)
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| Figure&Table&Reference;FIG.3, TBL.2, REF.19 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The aim of this study was to compare cilnidipine and other calcium channel blockers (CCB) with respect to their effects on urinary albumin excretion (UAE) and urinary fibronectin (U-Fn) in diabetic nephropathy. Hypertensive type 2 diabetes patients (n=32) with micro-albuminuria, who had been treated with nifedipine (n=16) or amlodipine (n=16), were randomly assigned to two groups. The half of the subjects (group I; n=16) were maintained on the therapy with nifedipine (n=8) and amlodipine (n=8). In another half of the subjects (group II; n=16), nifedipine and amlodipine were switched to cilnidipine. Before and at 6 and 12 months after randomization, UAE and U-Fn in the first morning urine were determined. There were no significant changes in blood pressure, HbA1c, and lipid parameters in either group throughout the study. Both of UAE and U-Fn levels were significantly decreased in group II at 6 and 12 months, while no significant alterations were observed in group I. These results suggest that cilnidipine is a more effective CCB than other CCBs as a treatment for incipient diabetic nephropathy. (author abst.) |
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