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High-Sensitivity C-Reactive Protein and Parameters of Left Ventricular Dysfunction

Accession number;06A0128129

Title;High-Sensitivity C-Reactive Protein and Parameters of Left Ventricular Dysfunction

Author; SHAH SANJIV J. (From The Div. Of Cardiology, Dep. Of Medicine, Univ. Of California, San Francisco) MARCUS GREGORY M. (From The Div. Of Cardiology, Dep. Of Medicine, Univ. Of California, San Francisco) GERBER IVOR L. (From The Div. Of Cardiology, Dep. Of Medicine, Univ. Of California, San Francisco) MCKEOWN BARRY H. (From The Div. Of Cardiology, Dep. Of Medicine, Univ. Of California, San Francisco) VESSEY JOSHUA C. (From The Div. Of Cardiology, Dep. Of Medicine, Univ. Of California, San Francisco) JORDAN MARK V. (From The Div. Of Cardiology, Dep. Of Medicine, Univ. Of California, San Francisco) HUDDLESTON MICHELE (From The Div. Of Cardiology, Dep. Of Medicine, Univ. Of California, San Francisco) FOSTER ELYSE (From The Div. Of Cardiology, Dep. Of Medicine, Univ. Of California, San Francisco) CHATTERJEE KANU (From The Div. Of Cardiology, Dep. Of Medicine, Univ. Of California, San Francisco) MICHAELS ANDREW D. (From The Div. Of Cardiology, Dep. Of Medicine, Univ. Of California, San Francisco)

Journal Title;J Card Fail

Journal Code:W1342A

ISSN:1071-9164

VOL.12;NO.1;PAGE.61-65(2006)

Figure&Table&Reference;FIG.1, TBL.3, REF.35

Pub. Country;United States

Language;English

Abstract;Elevated levels of high-sensitivity C-reactive protein (CRP), an inflammatory marker, have been associated with heart failure. However, it is not known which parameters of left ventricular dysfunction correlate with elevated levels of CRP. In this cross-sectional study of 98 patients referred for cardiac catheterization, we investigated whether commonly used clinical indices of left ventricular dysfunction correlated with CRP levels. CRP levels were elevated to a greater degree in participants with diabetes mellitus (P =.006) and heart failure (P =.003). Increased CRP levels were associated with increased plasma levels of B-type natriuretic peptide (BNP; P =.0001), decreased left ventricular ejection fraction (LVEF; P =.02), and increased left-ventricular end-diastolic pressure (LVEDP; P =.0005). After multivariable adjustment, LVEDP and CRP were independently associated (P =.046). CRP is increased in patients with heart failure. Of the clinical parameters of left ventricular dysfunction, direct measurement of left ventricular end-diastolic pressure is most closely associated with CRP. Copyright 2006 Elsevier B.V., Amsterdam.All rights reserved.

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