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Accession number;06A0281881
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| Title;Development of high frequency direct current pulse-type iontophoresis and its clinical application |
| Author;
AKIMOTO MAKIO
(Kanto Gakuin Univ., Coll. Engineering, JPN)
OMI TOKUYA
(Kuinzusukueamedikaruse)
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Journal Title;Aesthetic Dermatol
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Journal Code:L5200A
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ISSN:1341-5530
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VOL.16;NO.1;PAGE.37-44(2006)
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| Figure&Table&Reference;FIG.7, TBL.2, REF.13 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Over the years, extensive research effort has been devoted to the development of noninvasive drug delivery techniques for the controlled systemic delivery of therapeutic peptides and proteins through various easily accessible tissues. Iontophoresis has recently been discovered as a potential drug delivery technique for the noninvasive, programmed systemic delivery of peptide and protein drugs. In this paper, the feasibility of using iontophoretic delivery devices to facilitate the transdermal transport of some drugs across the skin is demonstrated. In vivo pharmacokinetics and pharmacodynamic studies in diabetic animals suggested that the systemic bioavailability of peptides and proteins are dependent upon the electronic variables of the iontophoretic delivery device, e.g. frequency, on/off ratio and intensity of the current applied, physiochemical parameters. The mechanism of the iontophoresis transdermal transport of peptide macromolecules is analyzed. (author abst.) |
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