Science Links Japan | The Relationship Between Aldosterone, Oxidative Stress, and Inflammation in Chronic, Stable Human Heart Failure

The Relationship Between Aldosterone, Oxidative Stress, and Inflammation in Chronic, Stable Human Heart Failure

Accession number;06A0161719

Title;The Relationship Between Aldosterone, Oxidative Stress, and Inflammation in Chronic, Stable Human Heart Failure

Author; KOTLYAR EUGENE (From The Cardiovascular Section, Evans Dep. Of Medicine) VITA JOSEPH A. (From The Cardiovascular Section, Evans Dep. Of Medicine) WINTER MICHAEL R. (School Of Public Health, Boston Univ., Boston, Massachusetts) AWTRY ERIC H. (From The Cardiovascular Section, Evans Dep. Of Medicine) SIWIK DEBORAH A. (Myocardial Biology Unit, Boston Univ.) KEANEY JOHN F. (From The Cardiovascular Section, Evans Dep. Of Medicine) SAWYER DOUGLAS B. (From The Cardiovascular Section, Evans Dep. Of Medicine) CUPPLES L. ADRIENNE (School Of Public Health, Boston Univ., Boston, Massachusetts) COLUCCI WILSON S. (From The Cardiovascular Section, Evans Dep. Of Medicine) COLUCCI WILSON S. (Myocardial Biology Unit, Boston Univ.) SAM FLORA (From The Cardiovascular Section, Evans Dep. Of Medicine) SAM FLORA (Myocardial Biology Unit, Boston Univ.)

Journal Title;J Card Fail

Journal Code:W1342A

ISSN:1071-9164

VOL.12;NO.2;PAGE.122-127(2006)

Figure&Table&Reference;FIG.1, TBL.4, REF.48

Pub. Country;United States

Language;English

Abstract;Aldosterone antagonists reduce morbidity and mortality in patients with severe heart failure, but the mechanisms responsible are not fully understood. Observations in animal models suggest that elevated levels of aldosterone promote oxidative stress and inflammation in the myocardium. It is unknown if these findings are relevant to heart failure patients who may have much lower aldosterone levels. We therefore examined the relationship of plasma aldosterone levels to markers of oxidative stress, inflammation and matrix turnover in 58 patients with chronic, stable heart failure from systolic dysfunction (LV ejection fraction <0.40) who were not receiving aldosterone antagonists. Chronic, stable heart failure patients had modestly elevated levels of aldosterone. Additionally, these patients had elevated levels of 8-isoprostaglandin F2.ALPHA., C-reactive protein, soluble intercellular adhesion molecule-1, osteopontin, brain natriuretic peptide, procollagen type III aminoterminal peptide, and tissue inhibitor of metalloproteinase-1. Among these patients with heart failure, aldosterone levels correlated with 8-iso-PGF2.ALPHA. (P = .003), ICAM-1 (P = .008), and TIMP-1 (P = .006) after adjustment for age, gender, race, diabetes, smoking, heart rate, left ventricular mass, and body mass index. In chronic, stable heart failure patients on standard therapy, higher aldosterone levels are associated with systemic evidence of oxidative stress, inflammation, and matrix turnover. Copyright 2006 Elsevier B.V., Amsterdam.All rights reserved.

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