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Accession number;06A0292924
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| Title;Medical Application of RNA Interference to Neuronal and Muscular Diseases. |
| Author;
HOJO HIROHIKO
(National Center of Neurology and Psychiatry, National Inst. Neuroscience, JPN)
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Journal Title;Neurological Therapeutics
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Journal Code:X0110A
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ISSN:0916-8443
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VOL.23;NO.1;PAGE.31-36(2006)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.21 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;RNA interference (RNAi) is the process of sequence-specific posttranscriptional gene silencing triggered by double-stranded RNAs (dsRNAs) homologous to the silenced genes. In terms of rapid and potent induction of RNAi by exogenous dsRNAs, RNAi become a powerful reverse genetic tool for suppressing the expression of a gene of interest in various species including mammals. In mammals including human, either direct introduction of chemically synthesized 21-25 nucleotide small interfering RNA (siRNA) duplexes into cells or generation of siRNA duplexes using short-hairpin RNA (shRNA) expression vector is often used for induction of RNAi, and its applications is expanding to various fields of science; therapeutic application of RNAi in medical fields is particularly promising. I herein describe the potential utility of RNAi technique against neuronal and muscular diseases and properties of RNAi activities in neuron and muscle cells which could be useful for realizing such an application of RNAi. (author abst.) |
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