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Accession number;06A0292926
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| Title;Early Effect of FK506 in Patients with Myastenia Gravis with Axonal Stimulated Single Fiber EMG |
| Author;
MATSUMOTO AKIHISA
(Sapporosibyouin)
TAJIMA YASUTAKA
(Sapporosibyouin)
SUDO KAZUMASA
(Sapporosibyouin)
TASHIRO KUNIO
(Health Sciences Univ. Hokkaido, School of Psychological Sci., JPN)
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Journal Title;Neurological Therapeutics
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Journal Code:X0110A
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ISSN:0916-8443
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VOL.23;NO.1;PAGE.45-49(2006)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.12 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;FK506 (tacrolimus) was used in 19 patients (age: 34-65 years) with generalized myasthenia gravis (MG). Duration of illness in 19 cases was 0.6-32.3 years (mean: 7.3 years), in 3 patients, clinical improvement was observed within 8 days after administration of FK506. The neural mechanism of early improvement was examined by axonal stimulated single fiber EMG (ASFEMG). Before administration of FK506, jitters were 75.MU.sec in case 1, 98.MU.sec in case 2 and 50.MU.sec in case 3. These jitters were decreased after administration of FK506 within 3-8 days as the clinical symptoms improved. In relation to changes of stimulus frequencies, jitters were increased in 2 cases with the increase of stimulus frequency. In the other 1 case, jitters were inversely decreased with the increase of stimulus frequency. These studies indicate that FK506 may have the effect on the function of neuromuscular transmission. (author abst.) |
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