A Case of Cryptococcal Meningitis Effectively Treated with Combination Therapy of Fosfluconazole and Flucytosine: Penetration of Fluconazole into Cerebrospinal Fluid in the Treatment with Fosfluconazole
|
Accession number;06A0292927
|
| Title;A Case of Cryptococcal Meningitis Effectively Treated with Combination Therapy of Fosfluconazole and Flucytosine: Penetration of Fluconazole into Cerebrospinal Fluid in the Treatment with Fosfluconazole |
| Author;
NISHIYAMA TAKEHIKO
(School of Medicine, Yokohama City Univ., JPN)
BABA YASUHISA
(School of Medicine, Yokohama City Univ., JPN)
ENDO MASANAO
(School of Medicine, Yokohama City Univ., JPN)
KUROIWA YOSHIYUKI
(School of Medicine, Yokohama City Univ., JPN)
|
Journal Title;Neurological Therapeutics
|
Journal Code:X0110A
|
ISSN:0916-8443
|
|
VOL.23;NO.1;PAGE.51-55(2006)
|
| Figure&Table&Reference;FIG.2, REF.9 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;A 29-year-old woman was admitted to our hospital with suspicion of aseptic meningitis. She had been suspected of having sarcoidosis, and suffered from headache and drowsiness. Cerebrospinal fluid (CSF) analysis revealed cryptococcus neoformans. The patient was treated with fosfluconazole and flucytosine, and her clinical condition improved. During the treatment, she developed weakness of the right foot, and T2 weighted MRI scan showed spotty high intensity lesions in the white matter of the left frontal lobe. These lesions were suspected of acute disseminated encephalomyelitis (ADEM), the patient was treated with methylprednisolone. We measured fluconazole concentration in the CSF and the serum. Fosfluconazole attains excellent CSF concentration, but the concentration was decreased during the steroid therapy. (author abst.) |
|
|
|
Related Articles;
|
|
