Two Cases of Cerebral Infarction Patient with Paroxysmal Supraventricular Tachycardia (PSVT) after Cilostazol Therapy

Accession number;06A0292930
Title;Two Cases of Cerebral Infarction Patient with Paroxysmal Supraventricular Tachycardia (PSVT) after Cilostazol Therapy
Author; KONNO SHINGO (Toho Univ.) HIRATA AYAKO (Toho Univ.) NEMOTO HIROSHI (Toho Univ.) WAKATA NOBUO (Toho Univ.) KURIHARA TERUYUKI (Toho Univ.)
Journal Title;Neurological Therapeutics
Journal Code:X0110A
ISSN:0916-8443
VOL.23;NO.1;PAGE.69-73(2006)
Figure&Table&Reference;FIG.2, REF.12
Pub. Country;Japan
Language;Japanese
Abstract;Here we report two cases of paroxysmal supraventricular tachycardia (PSVT) caused by cilostazol. Case 1 (57-year-old man): He had no history of heart disease and visited to our hospital with a transient episode of left hemiparesis. Brain MRI showed multiple old infarctions, and he was placed on cilostazol 200mg/day. He developed dizziness and palpitation two days after taking cilostazol. Seven months later, he showed severe PSVT with hypotension. Valslava maneuver was effective for his PSVT without any medication. Case 2 (77-year-old woman): She also had no history of heart disease. She was admitted to our hospital because of pontine infarction. Ten days after the onset of infarction, she was placed on cilostazol 200mg/day. On the next day she developed PSVT, and it became resistant to treatment, since she also had influenza infection and had high fever. Valslava maneuver, ATP and verapamil hydrochloride injections were not effective to the PSVT; subsecuently pilsicanide hydrochloride was given and it was effective. We suspected that PSVT was caused by cilistazol, because PSVT did not re-appeared again after ceasing cilostazol. Previous literatures report that PSVT is caused by cilostazol when the patients have underlining heart disease. We would like to emphasize that we have to pay attention to the cardiac arrhythmia when we prescribe cilostazol to the patients even without any previous heart disease. (author abst.)