Predictive Factors of Outcome and Empirical Therapy in Patients with Central Nervous System Infection
|
Accession number;06A0292931
|
| Title;Predictive Factors of Outcome and Empirical Therapy in Patients with Central Nervous System Infection |
| Author;
INATOMI YUICHIRO
(Saiseikai Kumamoto Hospital, JPN)
YONEHARA TOSHIRO
(Saiseikai Kumamoto Hospital, JPN)
HASHIMOTO YOICHIRO
(Kumamoto City. Hospital, JPN)
HIRANO TERUYUKI
(Kumamoto Univ., JPN)
UCHINO MAKOTO
(Kumamoto Univ., JPN)
|
Journal Title;Neurological Therapeutics
|
Journal Code:X0110A
|
ISSN:0916-8443
|
|
VOL.23;NO.1;PAGE.75-81(2006)
|
| Figure&Table&Reference;FIG.3, REF.11 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Objective: To investigate predictive factors of outcome and efficacy of empirical combined therapy in patients with central nervous system infection. Materials and method: Forty-five patients with diagnosis of meningitis or encephalitis were satisfied with our inclusion criteria: modified Rankin Scale (mRS) before onset.LEQ.1; Glasgow coma scale.LEQ.14 or focal deficits of central nervous system. Study 1: Using multivariate statistical methods, the independent factors associated with favorite outcome at discharge were investigated. Study 2: patients who were admitted after October 2002 were treated with empirical combined therapy including penicillin, 3rd generation cephem or carbapenem, rifampicin, isoniazid, fluconazole, acyclovir, immunoglobulin and dexamethazone (EC group, n=18), and were retrospectively compared with a historical control cohort of similar patients treated with conventional therapy (control group, n=27). Results: Study 1: These subjects were divided into two groups; favorite outcome group (mRS at discharge.LEQ.1; 25 patients) and poor outcome group (mRS at discharge.GEQ.2; 20 patients). Independent and significant factors associated with favorite outcome was age (year/10; OR, 0.5; 95% CI, 0.3 to 0.9). Study 2: Death at discharge were seen in EC group less frequently than control group (0% vs 18%; p=0.140). Conclusion: Age was one and only independent factor associated with prognosis in patients with central nervous system infection. (author abst.) |
|
|
|
Related Articles;
|
|
