Blood levels of type II phospholipase A2 and platelet-activating factor acetylhydrolase are elevated in acute lung injury/acute respiratory distress syndrome
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Accession number;06A0314074
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| Title;Blood levels of type II phospholipase A2 and platelet-activating factor acetylhydrolase are elevated in acute lung injury/acute respiratory distress syndrome |
| Author;
MIYATA MICHIKO
(Iwate Medical Univ., Morioka, Jpn)
SATO NOBUHIRO
(Iwate Medical Univ., Morioka, Jpn)
KOJIKA MASAHIRO
(Iwate Medical Univ., Morioka, Jpn)
HAKOZAKI MASAKI
(Iwate Medical Univ., Morioka, Jpn)
IMAI SATOKO
(Iwate Medical Univ., Morioka, Jpn)
TAKAHASHI GAKU
(Iwate Medical Univ., Morioka, Jpn)
MAKABE HIDEYUKI
(Iwate Medical Univ., Morioka, Jpn)
SHIBATA SHIGEHIRO
(Iwate Medical Univ., Morioka, Jpn)
SHIOYA NOBUKI
(Iwate Medical Univ., Morioka, Jpn)
SUZUKI YASUSHI
(Iwate Medical Univ., Morioka, Jpn)
WAKABAYASHI GO
(Iwate Medical Univ., Morioka, Jpn)
ENDO SHIGEATSU
(Iwate Medical Univ., Morioka, Jpn)
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Journal Title;Med Postgrad
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Journal Code:X0599A
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ISSN:0285-4716
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VOL.44;NO.2;PAGE.188-194(2006)
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| Figure&Table&Reference;FIG.5, TBL.1, REF.37 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Blood levels of type II phospholipase A2 (type II PLA2) and platelet-activating factor acetylhydrolase (PAF-AH) were investigated in septic acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Type II PLA2 and PAF-AH levels were significantly higher in septic ALI/ARDS patients than in those without ALI/ARDS. There was a significant correlation between type II PLA2 and PAF-AH. The levels of endotoxin, tumor necrosis factor .ALPHA. (TNF-.ALPHA.), and interleukin 8 (IL-8) were also high at the time of septic ALI/ARDS onset. Correlations among these humeral mediators suggested endotoxin and cytokines to be involved in the production of type II PLA2 and PAF-AH. (author abst.) |
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