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Accession number;06A0382476
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| Title;Selective Inhibition Mechanism of Factor VIIa/Tissue Factor Revealed from X-ray Crystal Structure Analysis |
| Author;
KADONO SHOJIRO
(Chugai Pharm. Co., Ltd.)
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Journal Title;Journal of the Crystallographic Society of Japan
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Journal Code:G0232A
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ISSN:0369-4585
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VOL.48;NO.2;PAGE.147-152(2006)
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| Figure&Table&Reference;FIG.4, REF.13 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Factor VIIa/tissue factor is a key serine protease for initiation of blood coagulation. It is seen as promising target for the developing new anticoagulant drugs. X-ray crystal structures of human factor VIIa/tissue factor in complex with peptide mimetic inhibitors revealed important interactions for the selective inhibition of factor VIIa/tissue factor. These observations should provide some important information for a design of new factor VIIa selective inhibitors. (author abst.) |
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