Effect of Photodynamic Therapy with ATX-S 10 (Na) on Experimental Choroidal Neovascularization
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Accession number;06A0448123
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| Title;Effect of Photodynamic Therapy with ATX-S 10 (Na) on Experimental Choroidal Neovascularization |
| Author;
HIROSE TOKIHITO
(Nihon Univ., School of Medicine, JPN)
NAKAJIMA MASAMI
(Nihon Univ., School of Medicine, JPN)
KYO TETSUHIRO
(Nihon Univ., School of Medicine, JPN)
YUZAWA MITSUKO
(Nihon Univ., School of Medicine, JPN)
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Journal Title;Journal of Japanese Ophthalmological Society
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Journal Code:Z0666A
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ISSN:0029-0203
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VOL.110;NO.6;PAGE.445-453(2006)
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| Figure&Table&Reference;FIG.7, REF.14 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Purpose: To evaluate an appropriate irradiative condition for selective occlusion of experimental choroidal neovascularization (CNV) with photodynamic therapy (PDT) using ATX-S 10 (Na). Methods: Experimental CNV was induced in monkey eyes by laser photocoagulation. PDT (dose of irradiative energy 40 to 80 J/cm'2') was performed after 3.5 mg/kg of body weight intravenous injections of ATX-S 10 (Na). CNV and retinal vessel occlusion induced by PDT was evaluated by fluorescein angiography (FA) at 1 and 7 days after irradiation. If FA showed no fluorescein dye leakage from CNV at 1 and 7 days after irradiation, CNV was evaluated by histopathological analysis at 7 days after irradiation. Results: Within 30 to 33 minutes after ATX-S 10(Na) injection and irradiation with 50 to 60 J/cm'2', FA showed no fluorescein dye leakage from CNV and no closure of retinal vessels at 1 and 7 days after irradiation. Light micrographs showed occluded CNV, and retinal vessels remained patent and there was no apparent change in the inner layer of the retina. Conclusions: Irradiative condition of ATX-S10 (Na) 3.5 mg/kg was appropriate 30 to 33 minutes after ATX-S 10(Na) injection and irradiation with 50 to 60 J/cm'2'. (author abst.) |
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