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Accession number;06A0389878
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| Title;Opioid receptor agonist-antagonist |
| Author;
TAKAHASHI HIDENORI
(Teikyo Univ.)
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Journal Title;Pain Clinic
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Journal Code:G0739B
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ISSN:0388-4171
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VOL.27;NO.;PAGE.S59-S66(2006)
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| Figure&Table&Reference;TBL.1, REF.10 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Agonist-antagonists counteracts analgesis actions of narcotics like morphine with its specific pharmacologic effect against mu-opioid receptor. Pentazocine is a typical agonist-antagonist (mixed agonist-antagonist). Buprenorphine displays its analgesic action through mu receptor. Some drugs that exhibit analgesic action in different mechanisms are also classified as agonist-antagonists. Tramadol is one such drug. Characteristics of these agents should be further exploited to compensate the poverty of such agents approved in Japan. |
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