Two Cases of Epidermolysis Bullosa Acquisita
|
Accession number;06A0471973
|
| Title;Two Cases of Epidermolysis Bullosa Acquisita |
| Author;
YOKOMI AKINORI
(Nisseibyoin)
TSUJI MAKI
(Nisseibyoin)
SATO AYAKO
(Nisseibyoin)
OGIDO YUKO
(Nisseibyoin)
HIGASHIYAMA MARI
(Nisseibyoin)
NAKAMURA TOSHIAKI
(Osaka Univ., Fac. Medicine, JPN)
ISHII FUMITO
(School of Medicine, Kurume Univ., JPN)
HASHIMOTO TAKASHI
(School of Medicine, Kurume Univ., JPN)
|
Journal Title;Skin Research
|
Journal Code:Z0014C
|
ISSN:1347-1813
|
|
VOL.5;NO.2;PAGE.125-132(2006)
|
| Figure&Table&Reference;FIG.8, TBL.1, REF.34 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We report two cases of epidermolysis bullosa acquisita. Case 1, a 72-year-old man, visited us with blisters on the extremities. Physical examination revealed large bullae on the hands, lower legs and feet. Case 2, a 40-year old man, visited us with blisters and erosion on the whole body. Physical examination revealed large bullae and eryhema on the trunk and extremities. The oral mucosa was involved in the both cases. Hisitopathological examination disclosed subepidermal blister. Direct immunofluorescence showed deposits of IgG and C3 at the cutaneous basement membrane zone. Indirect immunofluorescence on salt-split skin demonstrated that the patient's IgG antibodies reacted with the dermal side of the split. Immunoblotting showed that the patients' serum reacted with 290-kDa epidermolysis bullosa acquisita antigen, and these cases were diagnosed as epidermolysis bullosa acquisita. Case 1 was treated with the systemic predonisolone and colchicine, but colchicine caused agranulocytosis. Therefore he was treated with the systemic predonisolone and dapsone. Case 2 responded well to the systemic prednisolone and dapsone. (author abst.) |
|
|
|
Related Articles;
|
|
|
