Two Cases of Systemic Sclerosis with Multiple Skin Ulcers and Gangrene
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Accession number;06A0471977
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| Title;Two Cases of Systemic Sclerosis with Multiple Skin Ulcers and Gangrene |
| Author;
ISHIBUCHI HIROHISA
(Gunma Univ., Graduate School of Medicine, JPN)
NAGAI YAYOI
(Gunma Univ., Graduate School of Medicine, JPN)
ENDO YUKIE
(Gunma Univ., Graduate School of Medicine, JPN)
OKADA ETSUKO
(Gunma Univ., Graduate School of Medicine, JPN)
TAGO OSAMU
(Gunma Univ., Graduate School of Medicine, JPN)
SUGAWARA NOBUYUKI
(Gunma Univ., Graduate School of Medicine, JPN)
MATSUSHIMA YOICHIRO
(Gunma Univ., Graduate School of Medicine, JPN)
TAMURA ATSUSHI
(Gunma Univ., Graduate School of Medicine, JPN)
ISHIKAWA OSAMU
(Gunma Univ., Graduate School of Medicine, JPN)
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Journal Title;Skin Research
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Journal Code:Z0014C
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ISSN:1347-1813
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VOL.5;NO.2;PAGE.148-152(2006)
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| Figure&Table&Reference;FIG.7, REF.12 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We presented two cases of diffuse cutaneous type of systemic sclerosis with multiple ulcers and gangrenous lesions on the feet and toes. The first case, a 46-year-old woman, presented with ulcers and purpura on her foot. When her ulcers worsened, elevated MPO-ANCA levels were noted. As renal dysfunction developed after her admission, predonisolone (PSL), 40mg/day, was orally administered under the diagnosis of ANCA-related nephritis. Although her renal function improved with the treatment, all her digits turned to be gangrenous. The second case, a 44-year-old woman, presented ulcers and gangrenous lesions on her feet and toes. Elevated MPO-ANCA levels were also noted. The treatment with oral PSL, 30mg/day, was started for deteriorating interstitial pneumonia. Arteriographic examination of the lower extremities showed stenosis and occlusion of plantar digital arteries, plantar artery and posterior tibial artery. In both patients, functional loss was minimized with conservative treatments. (author abst.) |
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