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Accession number;06A0484821
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| Title;Anti-Heterogenous Nuclear Ribonucleoprotein B1 Antibodies in Cerebrospinal Fluid of Multiple Sclerosis |
| Author;
YUKITAKE MOTOHIRO
(Saga Univ., JPN)
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Journal Title;Neurological Therapeutics
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Journal Code:X0110A
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ISSN:0916-8443
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VOL.23;NO.2;PAGE.99-105(2006)
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| Figure&Table&Reference;FIG.5, TBL.1, REF.24 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Heterogenous nuclear ribonucleoproteins (hnRNPs) play an important role as the autoantigens in not only systemic rheumatic diseases but also neurological diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and paraneoplastic neurological syndromes. Even in multiple sclerosis (MS), generally accepted cell-mediated autoimmune neurological disease against myelin proteins, the importance of humoral immunity has been discussed. We demonstrated here the high incidence of autoantibodies against hnRNP B1 in cerebrospinal fluid (CSF) of MS patient. The incidence of CSF anti-hnRNP B1 antibodies (Abs) was partucularly high in MS (91.4%, n=35), but no anti-hnRNP B1 Abs were observed in CSF of other neurological diseases including HAM/TSP (n=40). These findings suggested that the detection of Abs against hnRNP B1 in CSF of MS was specific enough to make it a disease marker for MS. In addition, anti-hnRNP B1 Abs might play an important rule in the pathogenesis of humoral immunity in MS. (author abst.) |
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