The Potential Role of Statins in the Treatment of Neurological Disorders
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Accession number;06A0484824
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| Title;The Potential Role of Statins in the Treatment of Neurological Disorders |
| Author;
KOORIYAMA TATSUO
(Hiroshima Univ., Graduate School, JPN)
MATSUMOTO MASAYASU
(Hiroshima Univ., Graduate School, JPN)
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Journal Title;Neurological Therapeutics
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Journal Code:X0110A
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ISSN:0916-8443
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VOL.23;NO.2;PAGE.121-132(2006)
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| Figure&Table&Reference;FIG.2, TBL.2, REF.44 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor (statins) potently inhibit cholesterol biosynthesis through inhibiting HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis. Several large clinical trials have demonstrated the beneficial effects of statins in the primary and secondary prevention of coronary heart disease. Recent clinical trials indicate that statins significantly reduce stroke risk in patients with coronary heart disease. The beneficial effects of statins in cardiovascular disease have been attributed to their cholesterol-lowering property. Recent experimental and clinical evidence indicates that some of the cholesterol-independent or pleiotropic effects of statins involved in endothelial function, cell proliferation, inflammatory response, immunological reactions, platelet function, and lipid oxidation. Many of these pleiotropic effects of statins are mediated by their ability to block the synthesis of important isoprenoid intermediates of cholesterol biosynthesis. In particular, the inhibition of small GTP-binding proteins, Rho, Ras, and Rac, may play an important role in mediating the pleiotropic effects of statins. Animal studies and observational clinical studies have indicated that statins might also be effective in treating certain neurological diseases such as multiple sclerosis and Alzheimer disease. Statins are promising candidates for future treatment in multiple sclerosis as they have been shown to exhibit immunomodulatory effects. Excess brain cholesterol has been associated with increased formation and deposition of amyloid-.BETA. peptide from amyloid precursor protein. Statins may not only inhibit enzymes involved in the endogenous synthesis of cholesterol but also affect enzymes involved in amyloid-.BETA. peptide metabolism.... (author abst.) |
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