Combination Therapy of Low-dose Methotrexate and Corticosteroid in the Treatment of Central Nervous System Sarcoidosis
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Accession number;06A0484826
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| Title;Combination Therapy of Low-dose Methotrexate and Corticosteroid in the Treatment of Central Nervous System Sarcoidosis |
| Author;
ONO SHIN'ICHI
(Nihon Univ., School of Medicine, JPN)
SUZUKI YUTAKA
(Nihon Univ., School of Medicine, JPN)
ISHIKAWA HARUMI
(Nihon Univ., School of Medicine, JPN)
MIZUTANI TOMOHIKO
(Nihon Univ., School of Medicine, JPN)
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Journal Title;Neurological Therapeutics
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Journal Code:X0110A
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ISSN:0916-8443
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VOL.23;NO.2;PAGE.139-144(2006)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We treated a 25-year-old man with central nervous system sarcoidosis who presented with meningoencephalitis. The patient had a fattv liver with slight elevations of hepatic enzyme levels. His meningoencephalitis was successfully treated using a high dose of corticosteroids (i.e., a 3-day consecutive intravenous administration of methylprednisolone at a dose of 1,000mg/day, followed by the oral administration of prednisolone (PSL) at a dose of 60mg/day). However, PSL dose tapering resulted in the relapse of the meningoencephalitis. A supplemental oral administration of methotrexate (MTX)(single dose of 10mg/week) allowed the PSL dose to be reduced to a level of 5mg/day without triggering a relapse. At present, the cumulative MTX dose is about 3,000mg, but no adverse effects from MTX have been encountered. We propose that lowdose MTX, administered as a single dose of 10mg/week, may be useful as a corticosteroidsparing agent in the treatment of CNS sarcoidosis. (author abst.) |
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