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Accession number;06A0484827
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| Title;In Vitro Study of the Evaluation of Spontaneous Platelet Aggregation by the Treatment of Sodium Ozagrel and Argatroban in Patients with Acute Ischemic Stroke |
| Author;
YAMADA KOJI
(St. Marianna Univ. School of Medicine, JPN)
HIRAYAMA TOSHIKAZU
(St. Marianna Univ. School of Medicine, JPN)
YAZAKI NAOKO
(St. Marianna Univ. School of Medicine, JPN)
TAKAHASHI YOICHI
(St. Marianna Univ. School of Medicine, JPN)
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Journal Title;Neurological Therapeutics
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Journal Code:X0110A
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ISSN:0916-8443
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VOL.23;NO.2;PAGE.145-150(2006)
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| Figure&Table&Reference;FIG.3, REF.17 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;In order to evaluate the efficacy of sodium ozagrel and argatroban, we measured spontaneous platelet aggregation (SPA) in patients with acute ischemic stroke before therapy, using the platelet -rich plasmas added sodium ozagrel and argatroban in vitro. Subjects comprised 35 patients with acute ischemic stroke. Subtype diagnoses included atherothrombotic stroke (ATS;n=15), lacunar stroke (LS;n=7) and cardioembolic stroke (CES;n=13). SPA of sodium ozagrel group was significantly decreased in patients with ATS and LS. SPA of argatroban group was significantly decreased in patients with CES. The results seemed to be reasonable from the standpoint of the pharmacological effect of sodium ozagrel and argatroban. These findings suggest that the activation of SPA differs among the subtypes of ischemic stroke patients. (author abst.) |
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