Sustained Restoration of Autonomic Balance With Long- but Not Short-Acting Metoprolol in Patients With Heart Failure
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Accession number;06A0306317
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| Title;Sustained Restoration of Autonomic Balance With Long- but Not Short-Acting Metoprolol in Patients With Heart Failure |
| Author;
AQUILANTE CHRISTINA L.
(From The Univ. Of Florida Coll. Of Pharmacy, Dep. Of Pharmacy Practice, Gainesville, Florida)
TERRA STEVEN G.
(From The Univ. Of Florida Coll. Of Pharmacy, Dep. Of Pharmacy Practice, Gainesville, Florida)
SCHOFIELD RICHARD S.
(Veterans Administration Medical Center, Gainesville, Florida)
SCHOFIELD RICHARD S.
(Univ. Of Florida Coll. Of Medicine, Div. Of Cardiology; Gainesville, Florida)
PAULY DANIEL F.
(Univ. Of Florida Coll. Of Medicine, Div. Of Cardiology; Gainesville, Florida)
HATTON PATRICIA S.
(The Ohio State Univ., Div. Of Cardiovascular Medicine, Heart & Lung Res. Inst., Columbus Ohio)
BINKLEY PHILIP F.
(The Ohio State Univ., Div. Of Cardiovascular Medicine, Heart & Lung Res. Inst., Columbus Ohio)
JOHNSON JULIE A.
(From The Univ. Of Florida Coll. Of Pharmacy, Dep. Of Pharmacy Practice, Gainesville, Florida)
JOHNSON JULIE A.
(Univ. Of Florida Coll. Of Medicine, Div. Of Cardiology; Gainesville, Florida)
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Journal Title;J Card Fail
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Journal Code:W1342A
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ISSN:1071-9164
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VOL.12;NO.3;PAGE.171-176(2006)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.18 |
| Pub. Country;United States |
| Language;English |
| Abstract;The purpose of this study was to compare the effects of immediate-release (IR) metoprolol and extended-release (XL) metoprolol on measures of heart rate variability in chronic systolic heart failure patients. Thirteen metoprolol-treated heart failure patients were randomized to a 2-way crossover study of equal daily doses of metoprolol IR and metoprolol XL, each administered for 3 weeks. After each 3-week interval, patients underwent 24-hour Holter and ambulatory blood pressure monitoring. Over the entire 24-hour period, the ratio of high to total variability (normalized measure of parasympathetic activity) was significantly greater (P < .05), the ratio of low to total variability (normalized measure of sympathetic activity) was significantly lower (P < .05), and the ratio of high to low variability (index of parasympathetic to sympathetic balance) was greater (P < .08) for metoprolol XL compared with metoprolol IR. Over the entire 24-hour period, both systolic and diastolic blood pressure were significantly lower for metoprolol XL compared with metoprolol IR (P < .0001, and .0005, respectively). These data suggest that with twice daily dosing, metoprolol IR is inferior to metoprolol XL in its effects on heart rate variability, autonomic balance, and blood pressure in patients with heart failure. Copyright 2006 Elsevier B.V., Amsterdam.All rights reserved. |
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