Caffeine Prolongs Exercise Duration in Heart Failure
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Accession number;06A0306323
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| Title;Caffeine Prolongs Exercise Duration in Heart Failure |
| Author;
NOTARIUS CATHERINE F.
(From The Univ. Health Network And Mount Sinai Hospital, Div. Of Cardiology And Fac. Of Medicine, Univ. Of Toronto ...)
MORRIS BEVERLEY
(From The Univ. Health Network And Mount Sinai Hospital, Div. Of Cardiology And Fac. Of Medicine, Univ. Of Toronto ...)
FLORAS JOHN S.
(From The Univ. Health Network And Mount Sinai Hospital, Div. Of Cardiology And Fac. Of Medicine, Univ. Of Toronto ...)
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Journal Title;J Card Fail
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Journal Code:W1342A
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ISSN:1071-9164
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VOL.12;NO.3;PAGE.220-226(2006)
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| Figure&Table&Reference;FIG.2, TBL.4, REF.26 |
| Pub. Country;United States |
| Language;English |
| Abstract;Caffeine increases submaximal exercise performance in healthy young subjects; its effects on exercise tolerance in heart failure (HF) have not been characterized. To determine whether caffeine increases exercise tolerance in HF, caffeine (4 mg/kg intravenously, equivalent to 2 cups of coffee) or vehicle were infused into 10 treated HF patients (left ventricular ejection fraction 25 .+-. 2 %), and 10 age-matched normal subjects (N) on 2 separate days in a double-blind, randomized, crossover design. We measured heart rate, blood pressure, and ventilation at rest and during graded cycling (15 W/minute) to peak effort. Peak oxygen consumption was unaffected in either group. Mean exercise time was unchanged in N (1013 .+-. 87 versus 988 .+-. 107 seconds; P = .86) but was significantly increased by caffeine in HF (from 511 .+-. 28 to 560 .+-. 37 seconds; P = .004) despite an increase in peak minute ventilation (P < .05). Resting and peak blood pressures were higher after caffeine (P < .05) in HF, not N. Caffeine allows HF patients to exercise longer at peak effort. Copyright 2006 Elsevier B.V., Amsterdam.All rights reserved. |
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