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Accession number;06A0332351
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| Title;Nuclear Translocation of Phosphorylated STAT3 is Essential for bFGF-Induced Human Dermal Microvascular Endothelial Cell Migration |
| Author;
YAHATA YOKO
(Ehime Univ., School of Medicine, JPN)
SHIRAKATA YUJI
(Ehime Univ., School of Medicine, JPN)
HASHIMOTO KOJI
(Ehime Univ., School of Medicine, JPN)
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Journal Title;Skin Research
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Journal Code:Z0014C
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ISSN:1347-1813
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VOL.5;NO.Suppl.6;PAGE.1-6(2006)
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| Figure&Table&Reference;FIG.3, REF.27 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Basic fibroblast growth factor (bFGF) is essential in angiogenesis since it stimulates endothelial cell migration and proliferation. The mechanism of this growth factor in endothelial cell migration has not been well characterized in contrast to that of endothelial cell proliferation. We here studied the signal transduction pathway of bFGF in human dermal microvascular endothelial cell (HDMEC) migration. The implication of signal transducers and activators of transcription (STAT) 3 in keratinocyte migration has been reported. Several studies indicated that STAT is another important pathway downstream of bFGF. This led us to hypothesize that STAT3 phosphorylation plays a critical role in HDMEC migration. Therefore, we studied a role of STAT3 in the migration of HDMEC. HDMEC expressed a marked increase of phosphorylated STAT3 in the nuclear fraction after addition of bFGF by immunohistochemical staining. SOCS1 and SOCS3 mRNA also increased in HDMEC after stimulation of bFGF. These data demonstrate that STAT3 and its phosphorylation are involved in the downstream pathway of bFGF/bFGFR interaction and regulate bFGF-induced HDMEC migration. (author abst.) |
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