Mechanisms of skin fibrosis and model mouse
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Accession number;06A0332352
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| Title;Mechanisms of skin fibrosis and model mouse |
| Author;
CHUJO SONOKO
(Kanazawa Univ., JPN)
IGAWA YUKA
(Kanazawa Univ., JPN)
SHIRASAKI FUMIAKI
(Kanazawa Univ., JPN)
TAKEHARA KAZUHIKO
(Kanazawa Univ., JPN)
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Journal Title;Skin Research
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Journal Code:Z0014C
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ISSN:1347-1813
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VOL.5;NO.Suppl.6;PAGE.7-15(2006)
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| Figure&Table&Reference;FIG.6, REF.18 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Skin fibrotic disorders are understood to develop under the influence of some growth factors, such as transforming growth factor-beta (TGF-.BETA.), basic fibroblast growth factor (b-FGF), or connective tissue growth factor (CTGF). To establish an appropriate animal model of skin fibrosis by exogenous application of growth factors, we investigated the effects of growth factors in vivo by injecting TGF-.BETA., CTGF and bFGF into subcutaneous tissue of newborn mice. A single application of TGF-.BETA. resulted in the formation of transient granulated tissue that disappeared despite 7 days of consecutive injections. However, persistent fibrosis was observed when CTGF was injected from 4 to 7 days after TGF-.BETA. injections for the first 3 days. Also, injecting TGF-.BETA. plus bFGF produced fibrotic tissue. Thus, we succeeded in established an animal model of skin fibrotic disorders by the exogenous application of growth factors, and this animal model will be useful for future studies in this area. (author abst.) |
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