Distinatinat chavac Teristics of human dermal fibroblasts depending on body-site: Divedrseresponse to basic fibroblast growth factor (bFGF)
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Accession number;06A0332354
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| Title;Distinatinat chavac Teristics of human dermal fibroblasts depending on body-site: Divedrseresponse to basic fibroblast growth factor (bFGF) |
| Author;
YASUDA MASAHITO
(Gunma Univ., JPN)
ISHIKAWA OSAMU
(Gunma Univ., JPN)
TAKAHASHI KENZO
(Kyoto Univ., Graduate School of Medicine, JPN)
MIYACHI YOSHIKI
(Kyoto Univ., Graduate School of Medicine, JPN)
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Journal Title;Skin Research
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Journal Code:Z0014C
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ISSN:1347-1813
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VOL.5;NO.Suppl.6;PAGE.21-25(2006)
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| Figure&Table&Reference;REF.18 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Human skin, especially epidermis, shows various morphological characteristics depending on the body-site, such as scalp, face, lip, trunk, palmoplantar and so on. Although the differences have been explained by the number of skin appendages or the variance of epidermal keratinocytes, it was recently elucidated that dermal fibroblasts showed biochemical characteristics depending on body-site. In order to reveal site-specific characteristic of tinnk, palroplactor skin or oral incosa by gene aiorry, we compared the expressions of the extracellular matrix and adhesion molecinles among fibroblasts of those body sites. As the result, we elucidated that fibroblasts showed various site-specific gene expressions. Furthermore, in order to examine differences of site-specific fibroblasts in wound healing, we analyzed the response to basic fibroblast growth factor. Proliferative rate of oral mucosal fibroblasts was accelerated more than trunk or palmoplantar skin. The mechanism is unclear. However, it might be a factor that oral mucosa heals faster than other body-sites. (author abst.) |
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