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Accession number;06A0332357
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| Title;Healing Stimulatory Effect of bFGF (Fiblast spray) on the Wounds Prepared in Reconstructed Human Skin and in Rabbit Ear Skin |
| Author;
ARAI KEITARO
(Tokyo Medical Univ., JPN)
JIN LONG
(Tokyo Medical Univ., JPN)
TSUBOI RYOJI
(Tokyo Medical Univ., JPN)
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Journal Title;Skin Research
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Journal Code:Z0014C
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ISSN:1347-1813
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VOL.5;NO.Suppl.6;PAGE.35-39(2006)
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| Figure&Table&Reference;FIG.4, REF.12 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The stimulatory effect of basic fibroblast growth factor (bFGF, Fiblast spray) on healing in wounds prepared in vitro in reconstructed human skin and in vivo in rabbit ear skin was histologically evaluated. In the in vitro in study, bFGF showed the strongest stimulatory effect on reepithelialization, at a dose of 0.1.MU.g/cm'2', similar to that induced by PDGF-BB. Likewise, in the in vivo wound model using 6mm-size rounded full-thickness skin wounds, the bFGF treated group (1.0.MU.g/cm'2') showed significant stimulation of reepithelialization and granulation tissue formation (p<0.05). These results suggest that bFGF stimulates wound healing by enhancing reepithelialization as well as granulation tissue formation. (author abst.) |
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