Delayed Wound Healing by the Absence of Cell Adhesion Molecules: Effect of cell Growth Factors

Accession number;06A0332358
Title;Delayed Wound Healing by the Absence of Cell Adhesion Molecules: Effect of cell Growth Factors
Author; SATO SHIN'ICHI (Nagasaki Univ.)
Journal Title;Skin Research
Journal Code:Z0014C
ISSN:1347-1813
VOL.5;NO.Suppl.6;PAGE.40-45(2006)
Figure&Table&Reference;FIG.5, REF.25
Pub. Country;Japan
Language;Japanese
Abstract;During the wound healing process, inflammatory cell infiltration induces inflammatory process and promotes the wound healing by producing various growth factors and proinflammatory cytokines. This inflammatory cell infiltration is the process that is highly regulated by multiple cell adhesion molecule expression. Consistent with this notion, the would healing is delayed in mice lacking cell adhesion molecules. This delayed would healing by the absence of cell adhesion molecules is normalized by treatment with basic fibroblast growth factor. This indicates that basic fibroblast growth factor plays an important and critical role in the wound healing process. (author abst.)