Significant Expression of Endoglin (CD105), TGF.BETA.-1 and TGF.BETA. R-2 in the Atherosclerotic Aorta: An Immunohistological Study
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Accession number;06A0462849
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| Title;Significant Expression of Endoglin (CD105), TGF.BETA.-1 and TGF.BETA. R-2 in the Atherosclerotic Aorta: An Immunohistological Study |
| Author;
PIAO MEIHUA
(Department of Pathology and Biodefense, Saga University Faculty of Medicine, Saga, Japan.)
TOKUNAGA OSAMU
(Department of Pathology and Biodefense, Saga University Faculty of Medicine, Saga, Japan.)
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Journal Title;J Atheroscler Thromb
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Journal Code:L2187A
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ISSN:1340-3478
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VOL.13;NO.2;PAGE.82-89 (J-STAGE)(2006)
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| Figure&Table&Reference;FIG.3, TBL.2, REF.29 |
| Pub. Country;Japan |
| Language;English |
| Abstract;To date, the glycoprotein endoglin and its receptor complex, formed between TGF.BETA. and TGF.BETA. R-2, have been studied in tumor angiogenesis. The purpose of this study is to investigate the expression profile of endoglin and its receptor complex in human atherosclerotic lesions, and compare it to that in non-atherosclerotic tissues. Twenty-six atherosclerotic lesions and twenty-six non-atherosclerotic aortic tissues were collected from thirty-six autopsy cases. Indirect immunohistochemical staining was performed to detect the presence of endoglin, TGF.BETA.-1, and TGF.BETA. R-2 proteins in aortic tissues. Endoglin expression was observed in smooth muscle cells (SMC), macrophages and endothelial cells of aortic atherosclerotic lesions. The levels of TGF.BETA.-1 and TGF.BETA. R-2 were increased in the intimal matrices, smooth muscle cells, and macrophages, as well as in endothelial cells. The expression levels of endoglin, TGF.BETA.-1, and TGF.BETA. R-2 were higher in atherosclerotic lesions than in non-atherosclerotic aortic tissues (p < 0.0001), and there was a correlation among the expression of endoglin, TGF.BETA.-1, and TGF.BETA. R-2 in atherosclerotic aortic lesions (p < 0.001). Endoglin or its receptor complex may participate in the atherogenesis. (Author abst.) |
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