Efficacy of a Low Dose of Pitavastatin Compared with Atorvastatin in Primary Hyperlipidemia: Results of a 12-week, open label study
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Accession number;06A0462853
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| Title;Efficacy of a Low Dose of Pitavastatin Compared with Atorvastatin in Primary Hyperlipidemia: Results of a 12-week, open label study |
| Author;
YOSHITOMI YUJI
(Miyauchi Makoto Memorial Clinic, Shizuoka, Japan.)
ISHII TOSHIKAZU
(Ishii Medical Clinic, Shizuoka, Japan.)
KANEKI MASASHI
(Kaneki Medical Clinic, Shizuoka, Japan.)
TSUJIBAYASHI TAKASHI
(Tsujibayashi Medical Clinic, Shizuoka, Japan.)
SAKURAI SHUN-ICHIRO
(Sakurai Medical Clinic, Shizuoka, Japan.)
NAGAKURA CHIEKO
(Miyauchi Makoto Memorial Clinic, Shizuoka, Japan.)
MIYAUCHI ATSUYOSHI
(Miyauchi Makoto Memorial Clinic, Shizuoka, Japan.)
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Journal Title;J Atheroscler Thromb
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Journal Code:L2187A
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ISSN:1340-3478
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VOL.13;NO.2;PAGE.108-113 (J-STAGE)(2006)
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| Figure&Table&Reference;TBL.4, REF.30 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Background: Pitavastatin has a potent cholesterol-lowering action. The clinical efficacy and safety of a low dose, 1 mg, of pitavastatin were examined. Methods: The effect of 12 weeks' treatment with pitavastatin 1 mg in an open label, non-randomized trial involving 137 patients with hypercholesterolemia as compared with treatment with atorvastatin 10 mg. Results: Total cholesterol, low-density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol and triglyceride (TG) levels at baseline did not differ between the two groups. At follow-up, there were no significant differences in total cholesterol, LDL cholesterol and HDL cholesterol levels between the groups. The TG levels at follow-up were higher in the pitavastatin group than atorvastatin group (p < 0.01). In patients with hyperlipidemia type IIa, TG levels at follow-up were lower in the atorvastatin subgroup (p < 0.01). However, there was no significant difference in TG levels at follow-up between the two subgroups in patients with hyperlipidemia type IIb. Conclusion: Pitavastatin 1 mg daily was safe and efficacious in reducing LDL cholesterol levels as compared with atorvastatin 10 mg daily. Further randomized comparative studies are needed to clarify the effect of a low dose of pitavastatin. (Author abst.) |
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