Role of skin-specific autoantigens and autoantibodies in the skin inflammation of a murine autoimmune lupus model
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Accession number;06A0543047
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| Title;Role of skin-specific autoantigens and autoantibodies in the skin inflammation of a murine autoimmune lupus model |
| Author;
NISHIMURA HIROYUKI
(Wakayama Medical Univ., JPN)
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Journal Title;Aesthetic Dermatol
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Journal Code:L5200A
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ISSN:1341-5530
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VOL.16;NO.2;PAGE.69-75(2006)
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| Figure&Table&Reference;FIG.2, REF.17 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Autoimmune lupus erythematosus (SLE) shows a variety of symptoms such as glomerulonephritis, arthritis, and skin inflammation. These symptoms are believed to be caused by immune complexes, the specificities of which are not tissue-specific like anti-nuclear component antibodies. These immune complexes, however, are not sufficient to explain tissue-specific inflammatory damage. The analysis of MRL lpr/lpr mice as a murine SLE model showed four respective tissue-specific autoantibodies to protein in the liver, spleen, skin and muscle. In particular, the skin-specific autoantibody was found to recognize desmosomal cadherin, desmoglein 3 as a tissue-specific autoantigen. Skin-specific autoantigen and autoantibody are discussed for their role in the development of skin disorders of SLE. (author abst.) |
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