Cutaneous pigmentation in patients with chronic renal failure on maintenance hemodialysis-quantitative analysis of skin lightness and its correlation with various uremic molecules-
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Accession number;06A0543051
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| Title;Cutaneous pigmentation in patients with chronic renal failure on maintenance hemodialysis-quantitative analysis of skin lightness and its correlation with various uremic molecules- |
| Author;
TANIGUCHI SHINKICHI
(Fac. Medicine, Wakayama Medical Univ., JPN)
SHIBATA MASANORI
(Koujukai Rihabiriteshonbyouin)
USAMI KAZUMASA
(Taigenkai Byoin)
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Journal Title;Aesthetic Dermatol
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Journal Code:L5200A
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ISSN:1341-5530
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VOL.16;NO.2;PAGE.95-101(2006)
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| Figure&Table&Reference;FIG.5, TBL.1, REF.14 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Skin lightness was quantitatively determined in 106 patients with chronic renal failure on maintenance hemodialysis and 137 non-dialytic patients, using a spectrophotometer, CR-400 (Konica Minolta). Skin lightness was significantly reduced in hemodialytic patients (p<0.01), and correlated with the serum level of creatinine (p<0.01), although no significant relationships were observed between serum BUN and uric acid levels, and between KT/V value. Decreased skin lightness that indicated increased cutaneous pigmentation in hemodialytic patients was also correlated with serum levels of intact parathyroid hormone, .ALPHA.1- and .BETA.2-microglobulins (p<0.05, p<0.01, and p<0.05, respectively). From these results, decreased skin lightness in hemodialytic patients is thought to originate from (a) certain serum molecule (s) whose molecular weights are about 10'4'-3*10'4' biochemically, and (b) probably because about 20 % of methylguanidine, a biological metabolite from creatinine, is present as a protein-bound non-dialyzable form in the serum. (author abst.) |
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