Percutaneous penetration of ascorbic acid by sonophoresis and iontophoresis
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Accession number;06A0543052
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| Title;Percutaneous penetration of ascorbic acid by sonophoresis and iontophoresis |
| Author;
MITSUI YUKIO
(Nihontennenbutsuken)
MUTO YOJIRO
(Nihontennenbutsuken)
TAIRA HITOMI
(Nihontennenbutsuken)
EBIHARA MUTSUHITO
(Oomiyahifukakurinikku)
ONISHI YOSHIHIRO
(Oonishihifukakurinikku)
FUJIMOTO NORIHIRO
(National Defense Medical Coll., JPN)
MATSUYAMA SHIGEO
(National Defense Medical Coll., JPN)
YAMAKAMI KAZUO
(National Defense Medical Coll., JPN)
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Journal Title;Aesthetic Dermatol
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Journal Code:L5200A
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ISSN:1341-5530
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VOL.16;NO.2;PAGE.102-108(2006)
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| Figure&Table&Reference;FIG.4, REF.14 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Vitamin C has several physiologic activities such as collagen synthesis, an antioxidative effect, and a demelanizing/melanin reduction effect. We previously determined the percutaneous absorption of '14'C-ascorbic acid by rat back skin and reported that iontophoresis promoted its absorption rather than simple application. This time, we tested the simple application, iontophoresis (single-use), sonophoresis (single-use) and combined use of iontophoresis and sonophoresis by rat back skin using '14'C-ascorbic acid and compared the permeability. The result revealed that the permeation rates by iontophoresis, sonophoresis and the combined use of iontophoresis and sonophoresis were higher in both the epidermis and dermis than by simple application. In particularly, the combined use of iontophoresis and sonophoresis showed much higher permeation in both the epidermis and dermis than the other treatments. Several consecutive human trial subjects (10 males aged from the in twenties to sixties) were enrolled after obraining informed consent. Combined treatment of iontophoresis and sonophoresis was administered to the cheek region of each test subject and then the metabolic deposition of collagen at the region was examined by measuring the amount of hydroxyproline (HyP). The amount of Hyp increased 2.2 times on average over a 3-month period. From these results, it was suggested that the combined use of iontophoresis and sonophoresis promoted the permeation of ascorbic acid and collagen synthesis. (author abst.) |
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