Nuclear matrix protein and tumor necrosis factor a levels in patients with septic acute lung injury/acute respiratory distress syndrome
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Accession number;06A0557950
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| Title;Nuclear matrix protein and tumor necrosis factor a levels in patients with septic acute lung injury/acute respiratory distress syndrome |
| Author;
HAKOZAKI MASANORI
(Iwate Medical Univ., Morioka)
SATO NOBUHIRO
(Iwate Medical Univ., Morioka)
KOJIKA MASAHIRO
(Iwate Medical Univ., Morioka)
IMAI SATOKO
(Iwate Medical Univ., Morioka)
TAKAHASHI GAKU
(Iwate Medical Univ., Morioka)
MIYATA MICHIKO
(Iwate Medical Univ., Morioka)
MAKABE HIDEYUKI
(Iwate Medical Univ., Morioka)
SHIBATA SHIGEHIRO
(Iwate Medical Univ., Morioka)
SHIOYA NOBUKI
(Iwate Medical Univ., Morioka)
SUZUKI YASUSHI
(Iwate Medical Univ., Morioka)
ENDO SHIGEATSU
(Iwate Medical Univ., Morioka)
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Journal Title;Med Postgrad
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Journal Code:X0599A
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ISSN:0285-4716
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VOL.44;NO.3;PAGE.283-287(2006)
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| Figure&Table&Reference;FIG.3, REF.28 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Blood levels of nuclear matrix protein (NMP), as an indicator of apoptosis, were measured in patients with septic acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). The subjects were 46 sepsis patients, 28 of whom had ALI/ARDS associated with sepsis. The blood NMP level was 822.+-.881 U/mL in the patients with ALI/ARDS, which was significantly higher than the 198.+-.171 U/mL in those without ALI/ARDS. The blood level of tumor necrosis factor a (TNF-.ALPHA.) was 180.+-.294 pg/mL in the patients with ALI/ARDS, which was significantly higher than the 40.+-.27 pg/mL in those without ALI/ARDS. There was also a significant (p = 0.0001) correlation between NMP and TNF-.ALPHA. levels (r = 0.5349). These results suggest apoptosis to be associated with septic ALI/ARDS and that TNF-.ALPHA. is involved in triggering apoptosis. (author abst.) |
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