Effects of Dai-saiko-to and/or colestimide on lipids in plasma and liver in mice fed a high fat diet
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Accession number;06A0557956
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| Title;Effects of Dai-saiko-to and/or colestimide on lipids in plasma and liver in mice fed a high fat diet |
| Author;
MURAO RAN
(Showa Pharmaceutical Univ.)
SHIOIRI TERUMI
(Kagawa Nutrition Univ., Saitama)
ONO HIROMI
(Kagawa Nutrition Univ., Saitama)
KUDO HIDEKI
(Kagawa Nutrition Univ., Saitama)
NOMURA MAKOTO
(Tokyo Medical And Dental Univ., Tokyo, Jpn)
SAKAMOTO SHINOBU
(Tokyo Medical And Dental Univ., Tokyo, Jpn)
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Journal Title;Med Postgrad
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Journal Code:X0599A
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ISSN:0285-4716
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VOL.44;NO.3;PAGE.317-323(2006)
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| Figure&Table&Reference;FIG.3, TBL.2, REF.11 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Dai-saiko-to [Da-chai-hu-tang (in Chinese)], a traditional Chinese herbal remedy, contains 8 components, has long been used as a hypocholesterolemic agent for liver disorders. Colestimide, a newly developed anion-exchange resin, is used for the treatment of hypercholesterolemia. It is not absorbed in the small intestine, but decreases the intestinal reabsorption of bile acids synthesized from cholesterol in the liver and consequently increases bile acid excretion into the feces. In the present study, we investigated the effects of Dai-saiko-to and/or colestimide on the body growth, the plasma levels of lipids and the liver in young male mice fed a high-fat diet. High-fat diet supplemented with Dai-saiko-to markedly reduced the plasma levels of lipids, liver weight, number of fatty droplets in liver cytoplasm and the body growth, compared with animals fed a high-fat diet alone. There were few differences in blood biochemistry among the groups. However, Dai-saiko-to slightly affected total protein, albumin, creatinine or calcium, and the activities of lactate dehydrogenase or cholinesterase. Colestimide alone reduced the plasma triglyceride levels, and decreased the liver weight when used with Dai-saiko-to. Thus, the action of Dai-saiko-to in anti-obesity, anti-hyperlipidemia and hepatocytic anti-hyperlipids seems effective, when used carefully. (author abst.) |
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