Oral Immunization of Common Carp with a Liposome Vaccine Containing Aeromonas hydrophila Antigen
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Accession number;06A0575249
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| Title;Oral Immunization of Common Carp with a Liposome Vaccine Containing Aeromonas hydrophila Antigen |
| Author;
YASUMOTO SHINYA
(Mie Univ., Mie, Jpn)
YOSHIMURA TETSURO
(Mie Univ., Mie, Jpn)
MIYAZAKI TERUO
(Mie Univ., Mie, Jpn)
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Journal Title;Fish Pathology
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Journal Code:G0015B
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ISSN:0388-788X
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VOL.41;NO.2;PAGE.45-49(2006)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.9 |
| Pub. Country;Japan |
| Language;English |
| Abstract;We developed a liposome vaccine in which Aeromonas hydrophila antigens were entrapped within the liposomal membrane compartment. Oral administration of the vaccine was found to immunize common carp Cyprinus carpio (mean body weight, 30g) against A. hydrophila. Two fish groups received the liposome vaccine (protein concentration, 33.MU.g/mL) at doses of 10 and 30.MU.L/fish/day for a period of 3 days. The levels of antibodies in the serum rose at 2 and 3wk post vaccination (p.v.) and then declined at 4wk p.v.. When fish groups orally immunized with a total of 30.MU.L/fish for 3 days were challenged by an intra-subcutaneous injection with live A.hydrophila at a dose of 3.0*10'5' or 1.0*10'6'CFU/fish at 22 days p.v., the fish were protected against the bacterial infection with RPS of 63.6 or 55.0%, respectively. (author abst.) |
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