A Possible Mechanism of Quinolone Resistance in Vibrio anguillarum
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Accession number;06A0575253
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| Title;A Possible Mechanism of Quinolone Resistance in Vibrio anguillarum |
| Author;
OKUDA JUN
(Hiroshima Univ., Higashi-hiroshima, Jpn)
KANAMARU SHUNSUKE
(Hiroshima Univ., Higashi-hiroshima, Jpn)
YUASA AKIHIKO
(Tokushima Agriculture, Forestry And Fisheries Technol. Support Center, Tokushima, Jpn)
NAKAOKA NORIYOSHI
(Ehime Prefectural Fish Disease Control Center, Ehime, Jpn)
KAWAKAMI HIDEMASA
(Ehime Prefectural Fish Disease Control Center, Ehime, Jpn)
NAKAI TOSHIHIRO
(Hiroshima Univ., Higashi-hiroshima, Jpn)
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Journal Title;Fish Pathology
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Journal Code:G0015B
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ISSN:0388-788X
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VOL.41;NO.2;PAGE.73-75(2006)
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| Figure&Table&Reference;TBL.2, REF.8 |
| Pub. Country;Japan |
| Language;English |
| Abstract;To study a possible quinolone resistance mechanism in Vibrio anguillarum, we examined gyrA and parC mutations among the oxolinic acid-resistant strains and laboratory-derived mutants. One point mutation only in the quinolone resistance-determining region (QRDR) of the gyrA gene was detected in one strain isolated from ayu Plecoglossus altivelis and laboratory-derived mutants with low-level resistance. On the other hand, point mutations in both the gyrA and parC QRDRs were detected in one strain isolated from ayu and a laboratory-derived mutant with highlevel resistance. These results suggest that as in other Gram-negative bacteria GyrA and ParC are the primary and secondary targets, respectively, of quinolone in V.anguillarum. (author abst.) |
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