28-Day Oral Toxicity of Macrophomopsis Gum in F344/DuCrj Rats
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Accession number;06A0586485
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| Title;28-Day Oral Toxicity of Macrophomopsis Gum in F344/DuCrj Rats |
| Author;
TAMANO SEIKO
(Dims Inst. Medical Sci., Inc.)
YOSHINO HIROKO
(Dims Inst. Medical Sci., Inc.)
YOSHINO HIROKO
(Nagoya City Univ. Graduate School Of Medical Sci.)
ICHIHARA TOSHIO
(Dims Inst. Medical Sci., Inc.)
ICHIHARA TOSHIO
(Nagoya City Univ. Graduate School Of Medical Sci.)
IMAI NORIO
(Dims Inst. Medical Sci., Inc.)
IMAI NORIO
(Nagoya City Univ. Graduate School Of Medical Sci.)
HAGIWARA AKIHIRO
(Dims Inst. Medical Sci., Inc.)
OMOTO TOSHIO
(San-ei Gen F.f.i., Inc.)
ASAI IWAO
(San-ei Gen F.f.i., Inc.)
NAKAMURA MIKIO
(San-ei Gen F.f.i., Inc.)
SHIRAI TOMOYUKI
(Nagoya City Univ. Graduate School Of Medical Sci.)
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Journal Title;Japanese Journal of Food Chemistry
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Journal Code:L4470A
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ISSN:1341-2094
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VOL.12;NO.3;PAGE.128-134(2005)
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| Figure&Table&Reference;FIG.1, TBL.4, REF.17 |
| Pub. Country;Japan |
| Language;English |
| Abstract;The potential toxicity of Macrophomopsis gum was investigated in groups of 6 F344 rats of each sex given powdered diet containing the compound at 0, 1.25, 2.5 or 5.0% for 28 days. Significant treatment-related effects of Macrophomopsis gum treatment included the following: lowered food efficiency in males and females of the 5.0% group. In leukocyte differentiation counts, lowered segment neutrophil values were observed in all male treated groups. Elongated prothrombin time was noted in the 2.5 and 5.0% male groups and elevated total bilirubin in the 2.5 and 5.0% female groups. Lowered total cholesterol values were noted in the 5.0% males and 2.5% females. Lowered phospholipid was noted in the 5.0% male group and lowered total protein in the 2.5 and 5.0% male groups. Lowered albumin was noted in the 2.5% male group. None of these minor variations observed in the food efficiency, hematology and blood biochemistry are considered to be indicative of any treatment-related toxic effect. In addition, no toxicologically significant treatment-related effects were noted regarding clinical signs, survival rate, body weights, food consumption, water intake, urinalyses, ophthalmology, gross pathology, organ weights and histopathology findings. The present results indicate that the no observed adverse effect level for 28 days dietary treatment is 5.0% (males: 3,956mg/kg/day, females: 4,257mg/kg/day). (author abst.) |
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