Analysis of the Factors Contributing to Serum Retinol Binding Protein and Transthyretin Levels in Japanese Adults
|
Accession number;06A0638955
|
| Title;Analysis of the Factors Contributing to Serum Retinol Binding Protein and Transthyretin Levels in Japanese Adults |
| Author;
YOSHIDA AKIHIRO
(Department of Clinical Laboratory, Nakatsugawa Municipal Hospital)
MATSUTANI YASUKO
(Div. of Nutrition & Health, School and Graduate School of Life Studies, Sugiyama Jogakuen University)
FUKUCHI YOSHIKO
(Div. of Nutrition & Health, School and Graduate School of Life Studies, Sugiyama Jogakuen University)
SAITO KENSUKE
(Marketing Division, Dade Behring)
NAITO MICHITAKA
(Div. of Nutrition & Health, School and Graduate School of Life Studies, Sugiyama Jogakuen University)
|
Journal Title;J Atheroscler Thromb
|
Journal Code:L2187A
|
ISSN:1340-3478
|
|
VOL.13;NO.4;PAGE.209-215 (J-STAGE)(2006)
|
| Figure&Table&Reference;TBL.4, REF.19 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Objective: We examined various factors possibly related to metabolic syndrome, particularly focusing on nutritional assessment proteins such as retinol binding protein (RBP) and transthyretin (TTR), and remnant lipoproteins.Materials and Methods: Fasting serum lipid was analyzed in 58 Japanese adult volunteers (33 men and 25 women, 42.5 .+-. 10.1 years old).Results: The lipid profiles of the subjects were classified by lipoprotein polyacrylamide gel electrophoretic patterns into Types S (n=10), A (n=37), and N (n=11), according to the method described in Internal Medicine 42: 244, 2003. RBP and TTR were significantly higher in Type N than in Types S and A. In multivariate analysis, RBP was accounted for by remnant-like particle-triglyceride (RLP-TG), interleukin 6, body mass index and low-density lipoprotein (LDL)-cholesterol (adjusted R'2' =0.621). TTR was accounted for by lipoprotein(a), adiponectin and RLP-TG (adjusted R'2' =0.415). Malondialdehyde-LDL was significantly accounted for by LDL-cholesterol and RLP-cholesterol (adjusted R'2' =0.601). Lipoprotein(a) and LDL-cholesterol were independent variables for oxidized LDL antigen (adjusted R'2' =0.620). High-sensitivity C-reactive protein was accounted for by interleukin 6, immunoreactive insulin and oxidized LDL antigen (adjusted R'2' =0.361). Uric acid and body mass index were independent variables for adiponectin (adjusted R'2' =0.429).Conclusion: RBP and TTR may be useful as convenient and simple clinical markers of overnutrition and possibly of metabolic syndrome. (Author abst.) |
|
|
|
Related Articles;
|
|
|
