The Anti-Atherosclerotic Effects of Lipid Lowering with Atorvastatin in Patients with Hypercholesterolemia
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Accession number;06A0638956
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| Title;The Anti-Atherosclerotic Effects of Lipid Lowering with Atorvastatin in Patients with Hypercholesterolemia |
| Author;
OZAKI KAZUYUKI
(Division of Cardiology, Niigata University Graduate School of Medical & Dental Sciences)
OZAKI KAZUYUKI
(Division of Cardiology, Takeda General Hospital)
KUBO TAKAAKI
(Division of Cardiology, Takeda General Hospital)
KUBO TAKAAKI
(Department of Internal Medicine & Cardiology, Kitasato University School of Medicine)
IMAKI RYUTA
(Department of Internal Medicine & Cardiology, Kitasato University School of Medicine)
SHINAGAWA HISAHITO
(Department of Internal Medicine & Cardiology, Kitasato University School of Medicine)
FUKAYA HIDEHIRA
(Division of Cardiology, Takeda General Hospital)
FUKAYA HIDEHIRA
(Department of Internal Medicine & Cardiology, Kitasato University School of Medicine)
OHTAKI KEITA
(Division of Cardiology, Niigata University Graduate School of Medical & Dental Sciences)
OHTAKI KEITA
(Division of Cardiology, Takeda General Hospital)
OZAKI SEIGA
(Division of Internal Medicine, Takeda General Hospital)
IZUMI TOHRU
(Department of Internal Medicine & Cardiology, Kitasato University School of Medicine)
AIZAWA YOSHIFUSA
(Division of Cardiology, Niigata University Graduate School of Medical & Dental Sciences)
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Journal Title;J Atheroscler Thromb
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Journal Code:L2187A
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ISSN:1340-3478
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VOL.13;NO.4;PAGE.216-219 (J-STAGE)(2006)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.22 |
| Pub. Country;Japan |
| Language;English |
| Abstract;We investigated the lipid lowering and anti-atherosclerotic effects of atorvastatin in patients with hypercholesterolemia. Thirty patients were given atorvastatin 10 mg daily, and assessed for serum lipids, intima-media thickness (IMT), and brachial-ankle pulse wave velocity (ba-PWV) at the baseline, 6 months, and 12 months. Remnant-like particle-cholesterol (RLP-C), lipoprotein (a)(Lp(a)), and high-sensitivity C-reactive protein (hs-CRP) were measured in some patients at the baseline and at 6 months. Total cholesterol, triglyceride and low-density lipoprotein cholesterol were significantly decreased by 32%, 23% and 44% at 6 months, respectively, and these effects were sustained at 12 months. There was no change in high-density lipoprotein cholesterol. IMT at the baseline was 0.88 .+-. 0.16 mm and decreased to 0.76 .+-. 0.13 mm at 6 months, remaining at 0.75 .+-. 0.12 mm at 12 months. We did not observe any significant changes in ba-PWV. RLP-C and hs-CRP were significantly reduced from 7.3 .+-. 10.8 mg/dL to 4.3 .+-. 5.3 mg/dL and 0.075 .+-. 0.065 mg/dL to 0.039 .+-. 0.043 mg/dL at 6 months, respectively. There was no change in Lp(a). The observed decrease in IMT suggests that atorvastatin possibly improves atherosclerosis, in addition to the significant reduction of serum lipids. (Author abst.) |
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