Effects of Benidipine Hydrochloride on Arterial Stiffness and Oxidative Stress in Hypertensive Patients with Type 2 Diabetes Mellitus
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Accession number;06A0673876
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| Title;Effects of Benidipine Hydrochloride on Arterial Stiffness and Oxidative Stress in Hypertensive Patients with Type 2 Diabetes Mellitus |
| Author;
YOKOYAMA HIROKI
(Jiyuugaokayokoyamanaikakurinikku)
TADA JUNKO
(Jiyuugaokayokoyamanaikakurinikku)
KURAMITSU MASAE
(Jiyuugaokayokoyamanaikakurinikku)
KOBAYASHI MASAYOSHI
(Kyowa Hakko Kogyo Co., Ltd., JPN)
KURIHARA OSAMU
(Kyowa Hakko Kogyo Co., Ltd., JPN)
KUROKI KAZUKO
(Kyowa Hakko Kogyo Co., Ltd., JPN)
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Journal Title;Ther Res
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Journal Code:Y0681A
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ISSN:0289-8020
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VOL.27;NO.8;PAGE.1589-1595(2006)
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| Figure&Table&Reference;FIG.4, TBL.2, REF.27 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The number of patients with atherosclerotic diseases is increasing, and diabetes mellitus and hypertension are known risk factors of atherosclerotic diseases. Furthermore, oxidative stress contributes to the onset and deterioration of atherosclerosis. We investigated the effect of a calcium channel antagonist, benidipine hydrochloride, on brachial-ankle pulse wave velocity (baPWV), as an index of arterial stiffness and the urinary excretion of 8-hydroxy-2'-deoxy-guanosine (8-OHdG), as an index of oxidative stress. Benidipine hydrochloride (4-8 mg/day) treatment for six months significantly decreased systolic blood pressure, diastolic blood pressure, mean blood pressure and pulse pressure. Furthermore, baPWV and the urinary excretion of 8-OHdG were significantly decreased by benidipine treatment. Our results suggest that benidipine may improve atherosclerosis and oxidative stress in hypertensive patients with type 2 diabetes mellitus, leading to inhibiting cardiovascular diseases. (author abst.) |
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