Effect of Angiotensin-converting Enzyme Inhibitor and Exercise on Hypertension and Aortic Wall Stiffness in Spontaneously Hypertensive Rats
|
Accession number;06A0673878
|
| Title;Effect of Angiotensin-converting Enzyme Inhibitor and Exercise on Hypertension and Aortic Wall Stiffness in Spontaneously Hypertensive Rats |
| Author;
GUO QI
(Tohoku Univ., Graduate School of Medicine, JPN)
MINAMI NAOYOSHI
(Tohoku Univ., Graduate School of Medicine, JPN)
KOZUKI MASAHIRO
(Tohoku Univ., Graduate School of Medicine, JPN)
|
Journal Title;Ther Res
|
Journal Code:Y0681A
|
ISSN:0289-8020
|
|
VOL.27;NO.8;PAGE.1605-1613(2006)
|
| Figure&Table&Reference;FIG.3, TBL.1, REF.34 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Background: Endurance exercise training is known to increase aortic compliance in normotensive rats and subjects. Objective: We investigated the effect of perindopril, an angiotensin-converting enzyme inhibitor (ACEi) alone, exercise alone, and their combination on blood pressure, cardiac and aortic hypertrophy, and aortic wall stiffness in spontaneously hypertensive rats (SHR). Methods: Male SHR aged 7 weeks were assigned to 4 groups: sedentary control, exercise, perindopril, and combination with perindopril and exercise. Exercise was performed on a treadmill 5 days/week for 60 min at 20 m/min, and perindopril (1 mg/kg/day) was administered by gavage. Systolic blood pressure (SBP) and heart rate (HR) were measured every week with the tail-cuff method. At the age of 15 weeks aortic wall stiffness was estimated by pulse wave velocity in the aorta. Cardiac and aortic hyper-trophy were evaluated by left ventricle/body weight (LV/BW) ratio and aorta/body weight (AO/BW) ratio, respectively. Results: Both exercise alone and perindopril alone significantly reduced SBP and HR, although antihypertensive effect of perindopril was greater than that of exercise. Perindopril, but not exercise, significantly reduced LV/BW, AO/BW, and aortic wall stiffness. Combination with perindopril and exercise had no additional effects to perindopril alone. Conclusions: We conclude that 1) aortic wall stiffness is closely related with aortic hypertrophy in growing SHR and 2) exercise training dose not modify aortic compliance of untreated- and ACEi-treated SHR. (author abst.) |
|
|
|
Related Articles;
|
|
