Review/Advances in Neurological Therapeutics (2005). Autonomic Nervous System Disorders.
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Accession number;06A0654490
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| Title;Review/Advances in Neurological Therapeutics (2005). Autonomic Nervous System Disorders. |
| Author;
TAMURA NAOTOSHI
(Saitama Medical School Junior Coll., JPN)
TAMURA NAOTOSHI
(Saitama Medical School, JPN)
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Journal Title;Neurological Therapeutics
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Journal Code:X0110A
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ISSN:0916-8443
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VOL.23;NO.4;PAGE.405-409(2006)
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| Figure&Table&Reference;REF.53 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;In this article, I reviewed literature published in 2005 that dealt with treatment of autonomic nervous system disorders. Recently, it has been recognized that most drugs used for orthostatic hypotension (OH) risk inducing supine hypertension and worsening vital prognosis. Therefore, non-pharmacological treatments (such as avoidance of sudden standing and supine position during daytime, drinking water, elastic stockings, head-up position during sleep) are recommended in the initial management of management for OH. Fludrocortisone was, however, reported to improve not only symptoms but also vital prognosis in patients with familial dysautonomia (Riley-Day syndrome). Although pure autonomic failure (PAF) has been considered as a clinical epiphenomena of Lewy body disease, the literature contained two case reports on patients with typical clinical features of PAF and antibodies binding to the nicotine acetylcholine receptor of the autonomic ganglia; one case was improved by plasma exchange, and another case by droxidopa. In Germany, a randomized controlled trial (RCT) indicated that Korodin, a herbal anti-OH preparation containing camphor and an extract from crataegus berries, was effective for OH. Moreover, a follow-up study of pyridostigmine, a cholinesterase inhibitor, showed that most patients were satisfied with this medication in the treatment of OH. Pyridostigrnine has also been reported effective in postural tachycardia syndrome (POTS). Furthermore, an RCT demonstrated the efficacy of fludrocortisone and salt in preventing syncope in children with POTS. Negative intrathoracic pressure during inspiration produced by an impedance threshold device, a valve attached to a facemask, was also suggested to be useful for preventing syncope.... (author abst.) |
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