Science Links Japan | A Case of the Syndrome of Inappropriate Secretion of Antidiuretic Hormone in Association with Acute Disseminated Encephalomyelitis that Improved with Steroid Therapy

A Case of the Syndrome of Inappropriate Secretion of Antidiuretic Hormone in Association with Acute Disseminated Encephalomyelitis that Improved with Steroid Therapy

Accession number;06A0654497

Title;A Case of the Syndrome of Inappropriate Secretion of Antidiuretic Hormone in Association with Acute Disseminated Encephalomyelitis that Improved with Steroid Therapy

Author; SAITO NAOSHI (Ohara Gen. Hosp.) SAITO NAOSHI (Fukushima Medical Univ., School of Medicine, JPN) OGATA MASAHIRO (Ohara Gen. Hosp.) OGATA MASAHIRO (Fukushima Medical Univ., School of Medicine, JPN) YAMAMOTO TEIJI (Fukushima Medical Univ., School of Medicine, JPN)

Journal Title;Neurological Therapeutics

Journal Code:X0110A

ISSN:0916-8443

VOL.23;NO.4;PAGE.451-454(2006)

Figure&Table&Reference;FIG.2, REF.11

Pub. Country;Japan

Language;Japanese

Abstract;A 47-year-old semicomatose man by acute disseminated encephalomyelitis (ADEM) developed episodes of hyponatremia (116mEq/l) by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). A MRI scan of the brain showed multiple high signal intensity lesions in the periventricular white matter and hypothalamus on T2-weighted and FLAIR images. The hyponatremia was resistant to the treatment with hypertonic Na infusions. However, he responded quickly to a short course of high-dose methylprednisolone with neurological recovery and normalization of hyponatremia. Although it is well known that SIADH may develop in the course of meningoencephalitis, this can occur rarely in multiple sclerosis. There has been no report of SIADH, however, in association with ADEM. This is perhaps the first report that inflammatory demyelinating lesions in the hypothalamus due to ADEM gave rise to an increased ADH secretion and hyponatremia. (author abst.)

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