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Accession number;06A0909594
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| Title;Therapeutic Application of Repetitive Transcranial Magnetic Stimulation for Epilepsy |
| Author;
AKAMATSU NAOKI
(Univ. Occupational and Environmental Health, School of Medicine, Dep. Neurology, JPN)
TSUJI SADATOSHI
(Univ. Occupational and Environmental Health, School of Medicine, Dep. Neurology, JPN)
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Journal Title;Neurological Therapeutics
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Journal Code:X0110A
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ISSN:0916-8443
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VOL.23;NO.5;PAGE.489-492(2006)
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| Figure&Table&Reference;REF.11 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;There has recently been an explosion of research into brain stimulation for treating neurological and mental disorders. Modulation of the brain activity by the repetitive transcranial magnetic stimulation (rTMS) is a new approach for the treatment of the intractable seizures. The experimental and clinical evidence of the lasting modulation of the cerebral activities such as motor cortex brought the researchers to try the rTMS as a treatment of epilepsy. Preliminary studies in small number of patients and case reports showed the efficacy of the rTMS for reducing the seizure rate in patients with intractable epilepsy. However, there is no study exists in large number of patients included that showed the efficacy of the rTMS currently. Animal studies in our laboratory showed efficacy of the rTMS for the treatment and prevention of the seizures and status epilepticus. The hypothesis of the underling mechanisms includes long term depression and enhancement of GABA-A transmission. However, further work is necessary to shed light on the mechanism of anti-seizure effects of rTMS. To establish a clinical indication in epilepsy therapy for rTMS, well-controlled multi-center randomized clinical trials with high numbers of patients are required. (author abst.) |
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