Effects of Repetitive Transcranial Magnetic Stimulation in Rats as a Model
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Accession number;06A0909596
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| Title;Effects of Repetitive Transcranial Magnetic Stimulation in Rats as a Model |
| Author;
CHUUMA TAKAYO
(Hokkaido Univ.)
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Journal Title;Neurological Therapeutics
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Journal Code:X0110A
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ISSN:0916-8443
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VOL.23;NO.5;PAGE.499-504(2006)
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| Figure&Table&Reference;FIG.6, REF.15 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Several studies were reported the effects of Repetitive transcranial magnetic stimulation (rTMS) in major depression, Parkinson's disease, spinocerebellar degeneration, dystonia, stroke, pain etc. Animal studies of rTMS treatment showed objective results and suggested therapeutic implications for central nervous system disorders. The reports of rat studies about effects of rTMS treatment on neurochemical changes showed the changes of extracellular serotonin (5-HT) and dopamine (DA) concentrations in the rat prefrontal cortex and the rat dorsolateral striatum. The frontal brain of each rat received acute rTMS treatment at 25Hz for 1s with 1-min intervals between trains (500pulses). Acute rTMS treatment of the frontal brain increased the extracellular DA concentrations in the rat dorsolateral striatum. Next, sham treatment increased the extracellular 5-HT levels in the rat prefrontal cortex, compared with the non-treat group and rTMS treatment group, and it might suggest that rTMS treatment eliminated the increase in 5-HT levels in the rat prefrontal cortex. Acute rTMS treatment of the frontal brain affects the DAergic neuronal system in the rat dorsolateral striatum. And, acute rTMS treatment of the frontal brain is related to the serotonergic neuronal system in the rat prefrontal cortex. Then, rTMS treatment might have therapeutic implications for Parkinson's disease and depression and other emotional disorders. (author abst.) |
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