Science Links Japan | The procalcitonin level does not elevate in the serum in deep mycosis

The procalcitonin level does not elevate in the serum in deep mycosis

Accession number;06A0874649

Title;The procalcitonin level does not elevate in the serum in deep mycosis

Author; SATO NOBUHIRO (Iwate Medical Univ. School Of Medicine, Morioka, Jpn) YAEGASHI YASUNORI (Iwate Medical Univ. School Of Medicine, Morioka, Jpn) OGAWA MASAAKI (Iwate Medical Univ. School Of Medicine, Morioka, Jpn) KOJIKA MASAHIRO (Iwate Medical Univ. School Of Medicine, Morioka, Jpn) MIYATA MICHIKO (Iwate Medical Univ. School Of Medicine, Morioka, Jpn) TAKAHASHI GAKU (Iwate Medical Univ. School Of Medicine, Morioka, Jpn) HAKOZAKI MASANORI (Iwate Medical Univ. School Of Medicine, Morioka, Jpn) KIKUCHI SATOSHI (Iwate Medical Univ. School Of Medicine, Morioka, Jpn) KASAI TAKESHI (Iwate Medical Univ. School Of Medicine, Morioka, Jpn) ENDO SHIGEATSU (Iwate Medical Univ. School Of Medicine, Morioka, Jpn)

Journal Title;Med Postgrad

Journal Code:X0599A

ISSN:0285-4716

VOL.44;NO.4;PAGE.386-391(2006)

Figure&Table&Reference;FIG.2, TBL.1, REF.20

Pub. Country;Japan

Language;English

Abstract;Purpose: Procalcitonin (PCT) is a calcitonin precursor, and there are as yet no detailed data regarding the significance of serum PCT levels in cases with deep mycotic infections. We determined the serum PCT, endotoxin (Et), and (1.RAR.3)-.BETA.-D-glucan (.BETA.-glucan) levels. Material and Methods: Number of patients were 15 with deep mycosis. The PCT level was determined by the chemoluminescence immunoassay. .BETA.-glucan was determined using the .BETA.-Glucan Test WAKO. Endotoxin was determined by the endotoxin-specific Endospesy test Results: All the patients tested positive for .BETA.-glucan in the serum. The PCT level exceeded 0.2 ng/mL in 7 of the 15 patients. All of these seven patients with deep mycotic infections, except one, also had mixed bacterial infection; three had mixed infection with Gram-positive bacteria and the other three had mixed infection with Gram-negative bacteria. All of the patients who had mixed infection with Gram-negative bacteria tested positive for Et in the serum. Conclusions: These results suggest that the PCT level in the serum is not increased in cases with deep mycotic infections, and that when the PCT level does exceed 0.2 ng/mL in cases with deep mycosis, mixed bacterial infection should be suspected. (author abst.)

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