Opsonic activity assessment of human intravenous immunoglobulin preparations against Candida albicans
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Accession number;06A0874651
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| Title;Opsonic activity assessment of human intravenous immunoglobulin preparations against Candida albicans |
| Author;
ONO YASUO
(Teikyo Univ. School Of Medicine, Tokyo, Jpn)
UBAGAI TSUNEYUKI
(Teikyo Univ. School Of Medicine, Tokyo, Jpn)
TANSHO SHIGERU
(Teikyo Univ. School Of Medicine, Tokyo, Jpn)
KOSHIO OSAMU
(Teikyo Univ. School Of Medicine, Tokyo, Jpn)
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Journal Title;Med Postgrad
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Journal Code:X0599A
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ISSN:0285-4716
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VOL.44;NO.4;PAGE.397-402(2006)
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| Figure&Table&Reference;FIG.3, REF.19 |
| Pub. Country;Japan |
| Language;English |
| Abstract;To elucidate the opsonic capabilities of a commercially available human intravenous immunoglobulin (IVIG) preparation against C.andida albicans, we have used the ability of opsonized yeasts to stimulate luminol-enhanced chemiluminescence (CL) of human polymorphonuclear leukocytes (PMN). The method was tested against 6 clinical isolates of C. albicans. Candida yeasts opsonized with IVIG resulted in a significant increase in PMN-CL (increase: 9.5 to 25.9 fold). The opsonization of Calbicans TIMM0239 was also enhanced by an Fc-intact IVIG preparation and the opsonic activity was dose-dependent. The same effect was shown in two different lots of an Fc-intact IVIG preparation. These results suggest that Fc-intact IVIG, which augments opsonic activity against C. albicans yeasts, may be a useful addition to the treatment of severe candidiasis in immunocompromised patients with impaired serum opsonic capacity. (author abst.) |
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