Effects of three endocrine-disrupting chemicals on 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors
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Accession number;06A0874653
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| Title;Effects of three endocrine-disrupting chemicals on 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors |
| Author;
KUDO HIDEKI
(Kagawa Nutrition Univ., Saitama)
AKAGI RISA
(Kagawa Nutrition Univ., Saitama)
KITANO MAI
(Kagawa Nutrition Univ., Saitama)
KON ASAKO
(Kagawa Nutrition Univ., Saitama)
MUKOUYAMA MASAKO
(Kagawa Nutrition Univ., Saitama)
OGIWARA MAI
(Kagawa Nutrition Univ., Saitama)
SUGIHO KANA
(Kagawa Nutrition Univ., Saitama)
SUZUKI SATOE
(Tokyo Medical And Dental Univ., Tokyo, Jpn)
SAKAMOTO SHINOBU
(Tokyo Medical And Dental Univ., Tokyo, Jpn)
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Journal Title;Med Postgrad
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Journal Code:X0599A
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ISSN:0285-4716
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VOL.44;NO.4;PAGE.408-414(2006)
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| Figure&Table&Reference;FIG.1, TBL.2, REF.30 |
| Pub. Country;Japan |
| Language;English |
| Abstract;We are increasingly exposed to environmental and occupational hazardous chemicals, which modulate hormonal activity and/or mutagenicity in mammals. Medroxyprogesterone acetate is a progesterone derivative which shows antiestrogenic, antiandrogenic, antigonadotropic and antitumor activities. A synthetic analog of ethinyltestosterone, danazol has weakly androgenic, strongly anti-androgenic and strongly antigonadotropic properties. Tamoxifen, an estrogen receptor blocker, is a non-steroidal triphenylethylene derivative which acts as an agonist and an antagonist of estrogen. In the present study, we investigated the effects of upper three chemicals, which were used in the clinical field and were not resolved into harmless products and remained on the earth as endocrine-disrupting chemicals, on the development of mammary tumors induced with 7,12-dimethyl-benz[a]anthracene in rats. Although tamoxifen did not affect the body growth, medroxyprogesterone acetate and danazol enhanced the body weight in mammary tumor-bearing rats. Three chemicals affected the tumor development with reduction of plasma estradiol levels, thymidine kinase activities and numbers of bromodeoxyuridine-immunoreactive (S-phase) cells in the tumors. Thus, the synthetic chemicals are beneficially effective in the clinical fields, but should be used strictly because of the presence of the adverse side, which could be environmental and occupational hazardous chemicals in the near future. (author abst.) |
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