Hepatocyte growth factor concentration in umbilical cord blood
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Accession number;06A0874654
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| Title;Hepatocyte growth factor concentration in umbilical cord blood |
| Author;
KOBATA RITSUYO
(Univ. Fukui, Fukui, Jpn)
TSUKAHARA HIROKAZU
(Univ. Fukui, Fukui, Jpn)
KAWATANI MASAO
(Univ. Fukui, Fukui, Jpn)
NISHIJIMA KOJI
(Univ. Fukui, Fukui, Jpn)
SHUKUNAMI KEN-ICHI
(Univ. Fukui, Fukui, Jpn)
KOTSUJI FUMIKAZU
(Univ. Fukui, Fukui, Jpn)
()
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Journal Title;Med Postgrad
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Journal Code:X0599A
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ISSN:0285-4716
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VOL.44;NO.4;PAGE.415-417(2006)
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| Figure&Table&Reference;REF.6 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Hepatocyte growth factor (HGF) exhibits multiple biological activities in a wide variety of cells. Several lines of evidence suggest an important role for HGF in organogenesis and angiogenesis in the fetus. Nevertheless, information about HGF formation for the human fetus remains limited. We measured umbilical venous serum concentrations of HGF using enzyme-linked immunosorbent assay in 45 Japanese newborns (male/female 21/24) with gestational age of 25-41 weeks and birth weights of 742-3292 g. We found that HGF concentrations in umbilical cord blood (422-1776 pg/mL) were significantly lower than those in healthy adult blood (1279-1990 pg/mL). Umbilical HGF concentrations (563-1377 pg/mL) in very premature newborns (9, born of non-preeclampsic mothers at 29 weeks of gestation or earlier) were comparable to those (422-1083 pg/m) in mature newborns (25, born of non-preeclampsic mothers at 35 weeks of gestation or later). We also noted that maternal preeclampsic condition (11, born of mothers having preeclampsia) did not influence markedly the umbilical venous HGF concentrations (439-1776 pg/mL vs. 422-1377 pg/mL). Considering that HGF concentrations in amniotic fluid samples obtained between 20 and 29 weeks were about 100 times higher than those in matched umbilical blood, we assume that maturation and growth of the fetal lung, digestive tract, and skin tissues might be promoted preferentially by HGF in amniotic fluid, rather than HGF in fetal circulation, during the second trimester of pregnancy. (author abst.) |
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